Document 0081
 DOCN  M9490081
 TI    Hybrid Ty virus-like particles.
 DT    9411
 AU    Adams SE; Burns NR; Layton GT; Kingsman AJ; British Bio-technology Ltd.,
       Oxford, U.K.
 SO    Int Rev Immunol. 1994;11(2):133-41. Unique Identifier : AIDSLINE
       MED/94321837
 AB    Vaccines need to activate antigen presenting cells, overcome genetic
       restriction in T-cell responses and elicit both T and B memory cells. In
       order to produce recombinant vaccines which can do this, considerable
       effort has been put into developing particulate antigen presentation
       systems to generate polyvalent, high molecular weight antigens which
       should maximally stimulate the immune system. One such antigen-carrier
       system is based on the ability of a protein encoded by the yeast
       retrotransposon, Ty, to self-assemble into virus-like particles (VLPs).
       Ty-fusion proteins retain this ability to form particles and a range of
       hybrid VLPs carrying a variety of heterologous antigens have been
       produced and shown to elicit potent immune responses. Hybrid VLPs
       carrying human immunodeficiency virus (HIV) antigens stimulate the three
       main components of the immune system, namely antibody synthesis, T-cell
       proliferative responses and cytotoxic T-lymphocyte (CTL) responses.
 DE    Animal  Antigen Presentation/IMMUNOLOGY  B-Lymphocytes/IMMUNOLOGY  *DNA
       Insertion Elements  Fungal Proteins/*IMMUNOLOGY  Genetic
       Vectors/*IMMUNOLOGY  Recombinant Fusion Proteins/*IMMUNOLOGY/PHYSIOLOGY
       Saccharomyces cerevisiae/*GENETICS  T-Lymphocytes,
       Helper-Inducer/IMMUNOLOGY  Viral Proteins/*IMMUNOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).